The release of the newest frontier AI models marks a turning point for cybersecurity. Within six months, advanced AI models with deep cybersecurity capabilities will become commonplace. The framework for defending against AI-driven threats is not completely new, but the standard for execution must be absolute. Organizations that are “mostly protected” are effectively unprotected. This document should serve as a CISO’s checklist with a phased approach that organizations should pursue to close gaps before attackers exploit them.